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Figure 5


Fig. 5. Mechanical probing of HSV-1 capsids. (A) A linear elastic response of capsids is observed when forces below 4.4 nN are applied (curves in light and dark blue). (B) The threshold loading force of 7 nN causes mechanical failure of the capsids. The linear curve (dark blue) was taken when the capsid was still intact, the next round of probing (red curve) has caused mechanical failure of the capsid. (C) Application of the loading force exceeding mechanical limits of the capsids. Linearity is lost at high force (curve in dark green), whereas at low force linear behavior is restored (curve in light green). Nevertheless, the stiffness of mechanically damaged capsids is dramatically reduced. (D) Application of guanidine hydrochloride induces genome release and consequently leads to decreased stiffness of the capsids (curve in light blue is taken from an intact capsid; that in light green from GuHCl-treated capsid). h1 to h8 represent the indentation values.





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