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Figure 5


Fig. 5. TRPC6-induced dendritic growth depends on CaMKIV activity. (A) Total lysates of cells treated as indicated blotted with antibodies to phosphorylated CaMKIV, total CaMKIV, phosphorylated CaMKII{alpha} or total CaMKII{alpha}. (B) Quantification of CaMKIV phosphorylation in the neurons transfected with the indicated constructs. *P<0.05 versus ctrl. (C) Representative images of the neurons transfected at 3 DIV for 4 days with wild-type TRPC6 (WTC6) and the dominant-negative CaMKIV mutant, or shTRPC6 RNAi construct and the constitutive active CaMKIV mutant. Scale bar: 20 µm. (D,E) Quantification of total dendritic tips (D) and total dendritic length (E) of the neurons shown in C. **P<0.01 versus ctrl. All data are the means ± s.e.m. n.s., not significant.





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