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Figure 7


Fig. 7. A putative mechanism for ApoB-crescent formation. (Top) Under normal conditions, lipid esters synthesized in the ER membrane continuously leave the ER membrane by forming LDs. LDs might leave the ER membrane by hatching, budding, or other mechanisms. In hepatocytes, LDs might recycle to the ER to supply lipids for VLDL formation. ApoB is co-translationally lipidated and acquires additional lipids to become mature VLDL. (Bottom) Abnormalities in lipidated ApoB might cause it to bind tightly to the ER membrane and arrest the LD departure from the ER. This results in the accumulation of lipid esters in the ER membrane and induces formation of the ApoB-crescent structure.





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