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First published online July 2, 2008

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TRPC6: channelling dendrite growth

In the growing brain, dendrites extend from the cell body of neurons – a process that is crucial for the development of neuronal circuits. The influx of Ca²⁺ (via NMDA receptors and voltage-sensitive Ca²⁺ channels) is important for dendritic growth, and Yizheng Wang and colleagues (p. 2301) now explore the role of TRPC6, a Ca²⁺-permeable nonselective cation channel, in this process. The authors show that the expression of TRPC6 in the rat hippocampus peaks between postnatal days 7 and 14 (a period of maximal dendritic outgrowth). In hippocampal cultures, they show, the overexpression of TRPC6 promotes dendritic growth and branching, both of which are impaired when TRPC6 is knocked down. Inhibiting Ca²⁺ influx blocks TRPC6-induced dendritic growth, and expressing dominant-negative mutants of CaMKIV or CREB has a similar effect; conversely, stimulating TRPC-dependent Ca²⁺ influx or expressing a constitutively active form of CamKIV both stimulate dendrite morphogenesis. Importantly, hippocampal dendrites grow longer and branch more in TRPC6 transgenic mice. TRPC6, therefore, promotes dendritic growth via the CamKIV-CREB pathway, and might have a crucial role in dendritic growth in vivo.

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TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway

Yilin Tai, Shengjie Feng, Ruiliang Ge, Wanlu Du, Xiaoxing Zhang, Zhuohao He, and Yizheng Wang
JCS 2008 121: 2301-2307. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?