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Fig. 1 Lsm4p has an N-rich C-terminal region. (A) The N-terminus of Lsm4p (aa 1-92) contains the Sm domain; the C-terminus (aa 93-187; boxed) contains N-rich (or Q-rich) stretches of variable lengths. Scer, S. cerevisiae; Spar, S. paradoxus; Sbay, S. bayanus; Smik, S. mikatae; Scas, S. castellii; Skud, S. kudriavzevii; Sklu, S. kluyveri. (B) Lsm4 protein alignment of the budding yeast (yLsm4p) and the human (hLsm4p) protein. Sequences were aligned using ClustalW. Q residues are highlighted in grey, N residues in black and RG (arginine-glycine) repeats are underlined.