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Figure 9


Fig. 9. New model for the role of the circumferential actin cables in junction development of confluent epithelial cells. (A) Newly proposed model for the role of the contraction of the circumferential actin cables in epithelial-junction development. In this model, the centripetal contractile force of the circumferential actomyosin cable (blue arrows) is counterbalanced by an aPKC-dependent putative centrifugal force (red arrows), such that it can be used for the development of continuous junction structures. Grey lines and circles, F-actin structures; dumb-bell-like symbols, myosin II; red circles, aPKC. (B) A previously published model suggesting that actomyosin contraction works at cell-cell-contact-free regions of the cell membrane in order to be used for lateral expansion of cell-cell contact regions (Adams et al., 1998; Gloushankova et al., 1997; Krendel and Bonder, 1999; Yamada and Nelson, 2007). (C) A possible mechanism by which the radial actin fibers are integrated into the circumferential actin cables. Grey lines and circles, F-actin structures; red circles, aPKC.





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