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Figure 3


Fig. 3. Crypt-villus architecture is disrupted in adult KO/Tg distal small intestine. (A-D) H&E-stained sections of distal small intestines. KO/Tg showed varying degrees of loss of normal crypt-villus architecture (A-C) and resembled colon (D). (E, F) Villus coalescence was clearly seen in cross sections. Note the crypt-like structures trapped in the center (arrow in F). The approximate positions of cross-sectioning are indicated by dashed lines in A and C. (G,H) Whole-mount views of intestine mucosa. KO/Tg small intestine (G) develops local flat epithelial surfaces (boxed area) with visible crypt mouths (arrow) that were also observed in normal colon (arrow and boxed area in H). (I-L) H&E stained sections of intestinal grafts. Lama5–/– small intestine grafts (J,K) failed to develop a normal crypt-villus architecture (I) but instead presented a colon-like architecture (L). Bars, 100 µm.





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