QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

	Help viewing high resolution images
	Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 6. Apical localization of Pard6 ${gamma}$ b within the neural tube does not require the PDZ domain. (A-C) Live 24 hpf embryos injected with H2b-mRFP and pard6 ${gamma}$ b^wt-GFP or pard6 ${gamma}$ b^KPLG-GFP mRNA as indicated (dorsal views of the neurocoel between the first and sixth somite). (A,B) In WT, both pard6 ${gamma}$ b^wt-GFP and pard6 ${gamma}$ b^KPLG-GFP localize along the apical ventricular surface of the neural tube (white arrowheads). (C) Within the pard6 ${gamma}$ b^s441 mutant background, pard6 ${gamma}$ b^KPLG-GFP localizes correctly to apical surfaces of the neural tube suggesting alternative modes of apical localization of pard6 ${gamma}$ b independent of the PDZ-domain-mediated association with Crb or Nok. (D-F) Localization of pard6 ${gamma}$ b^wt-GFP within the neural tube is dependent on either (E) Nok or (F) Ome/Crb2a. (H) Apical localization of Nok requires Ome/Crb2a. Orientation: all images are apical views.

Return to article