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Figure 6


Fig. 6. Model showing the coalescence of different lipid rafts. In resting cells, GM1 forms a lipid shell that surrounds the EGFR by binding to the ectodomain, and colocalizes in a cholesterol-dependent manner with GPI-GFP. Stimulation of the cell with EGF results in the coalescence of these two different microdomains possibly leading to the formation of signaling platforms and the initiation of EGFR internalization.





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