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Figure 6


Fig. 6. A schematic of a possible mechanism for Cin8-mediated anaphase midzone centering. SPBs, iMTs and their plus (+) and minus (–) ends, Cin8, midzone regions, and the regions of iMT plus-end dynamics (double-headed arrows) are indicated. (A) The WT spindle is shown, in which the normal MT-crosslinking function of Cin8 organizes the midzone MTs in a tight bundle. This tight midzone organization restricts the region of iMT plus-end dynamics to a small portion of the iMT length. (B) The Cin8-FA spindle is shown, in which the impaired MT-crosslinking function of Cin8 releases the midzone bundle, allows for the iMTs to be exchangeable throughout a larger portion of their length and uncouples the iMT plus-end dynamics of the two halves of the spindle. This can result in an asymmetric midzone location (bottom).





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