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Figure 3


Fig. 3. In vivo conditioned PN-DRG show enhanced BDNF-induced axonal outgrowth in the presence or absence of ActD. (A,B) Mean axonal outgrowth distances from (A) 3-day or (B) 5-day in vivo conditioned PN-DRG (hatched bars) and contralateral controls (open bars) after 3 days in collagen gels. BDNF enhances axonal outgrowth from control PN-DRG, but this response is greatly reduced by ActD. In vivo conditioned preparations show enhanced spontaneous and BDNF-induced axonal growth, even in the presence of ActD.





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