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Figure 5


Fig. 5. AG490 inhibits axonal growth in freshly dissected and in vitro conditioned PN-DRG. (A) Incubation of PN-DRG with AG490 (50 µM) for 3 days significantly reduced subsequent BDNF-induced axonal outgrowth in the presence or absence of ActD (P<0.001 or P<0.005, respectively). (B) However, BDNF-induced axonal outgrowth from both freshly dissected and conditioned preparations was also strongly inhibited in the presence of AG490 at concentrations as low as 2 µM (mean values from two pooled experiments).





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