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Figure 8


Fig. 8. Increased levels of secreted Spitz suppress the rough eye phenotype. The rough eye caused by transgenic expression of a truncated Glued product is suppressed by sSpitz overexpression. (A) When the {Delta}Gl transgene is driven by two copies of an actin-GAL4 driver, a rough-eye phenotype results. (B) The {Delta}Gl phenotype is significantly suppressed by coexpression of the secreted form of Spitz protein from a UAS-sSpitz transgene. Genotypes shown: (A) UASp-{Delta}Gl, act5c-GAL4/CyO; act5c-GAL4/+, and (B) UAS-sSpitz/UASp-{Delta}Gl, act5c-GAL4; act5c-GAL4/+.





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