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Figure 8


Fig. 8. Degradation of DQ-collagen-IV by living cells that migrate through Matrigel. Cells were incubated for 48 hours on Matrigel mixed with DQ-collagen-IV. (A) Degradation of DQ-collagen-IV by living MCF-10A neoT cells; green fluorescent degradation products of DQ-collagen-IV are present extracellularly and intracellularly. (B) Wild-type Jurkat T lymphocytes show no morphology changes and no fluorescent degradation products. (C) Cathepsin-X-overexpressing Jurkat T lymphocytes show a characteristic migratory phenotype and, similar to wild-type Jurkat T lymphocytes, no collagen degradation is observed. Scale bars, 20 µm (A) and 10 µm (B,C).





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