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Figure 6


Fig. 6. Fibrillin-1 microfibril assembly is disrupted in murine embryonic fibroblasts expressing mutant fibronectinRGE/RGE. Representative confocal microscopy images of microfibril assembly [using Santa Cruz N-19 anti-fibrillin-1 pAb (SC-7541); green, FITC] and fibronectin assembly (using FN-3E2 mAb to cellular fibronectin; Texas Red) by nonpermeabilised wild-type or fibronectinRGE/RGE mutant MEFs, at 14 days. Cell nuclei were stained with DAPI (blue). Mutant cells deposited reduced fibronectin and very little extracellular fibrillin-1. Scale bars: 50 µm. Enlarged images are also shown. These experiments were repeated three times.





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