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Figure 6


Fig. 6. β-catenin phosphorylation at Y142 regulates axon growth induced by HGF. (A) Hippocampal neurons transfected with EYFP alone (control) or with EYFP and WT or mutant (Y654F or Y142F) β-catenin. HGF (50 ng/ml) induces axon growth in neurons expressing WT or Y654F β-catenin, but HGF-induced axon growth is inhibited in neurons expressing the mutation Y142F. Scale bar: 40 µm. (B) Quantification of axon length normalized to the respective control shows that HGF increases axon length in neurons expressing WT or Y654F β-catenin, but not in neurons expressing Y142F. (C) Quantification of axon branching shows that HGF treatment induces axon branching that is blocked by the Y142F mutation (*P≤0.05, **P≤0.01; n=4-7 experiments).





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