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Fig. 5. Mutants ${Delta}$ 2-8 and ${Delta}$ 9-21 did not produce conducting hemichannels, but coexpression of either one with wild-type CX37 inhibited currents produced from wild-type CX37. (A) Current-voltage relationships for control oocytes (x), wild-type CX37 ( $bullet$ ), ${Delta}$ 2-8 ( ${Delta}$ ) and differing ratios of ${Delta}$ 2-8 coexpressed with wild-type CX37 ( ${square}$ , 1:1; ${diamond}$ , 0.2:1; ${triangledown}$ , 0.05:1). (B) Current-voltage relationships for wild-type CX37 ( $bullet$ ), ${Delta}$ 9-21 ( ${Delta}$ ), and differing ratios of ${Delta}$ 9-21 coexpressed with wild-type CX37 ( ${square}$ , 1:1; ${diamond}$ , 0.2:1; ${circ}$ , 0.1:1). (C,D) Graphs of mole fraction vs fractional current for ${Delta}$ 2-8 coexpressed with wild-type CX37 (C) and for ${Delta}$ 9-21 coexpressed with wild-type CX37 (D). Curves represent the theoretical values for inhibition by one (lower) or two (upper) mutant subunits within a hemichannel. Both ${Delta}$ 2-8 and ${Delta}$ 9-21 fit closely to the curve for inhibition of hemichannel function by one mutant subunit. Data are shown as mean ± s.e.m.

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