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Figure 6


Fig. 6. A mutant containing alanine residues substituted for the amino acids at positions 2-8 formed plaques in transfected HeLa cells, did not form functional hemichannels but inhibited wild-type CX37 function. (A) Fluorescence microscopic localization of 2-8Ala in HeLa cells after transient transfection. Scale bar: 20 µm. (B) Current-voltage relationships for control oocytes (x), wild-type CX37 (bullet), 2-8Ala ({Delta}) and 2-8Ala coexpressed with wild-type CX37 at a 1:1 ratio ({square}). Data are shown as mean ± s.e.m.





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