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Figure 6


Fig. 6. The membrane proximal part of the C-terminus and the DRY motif of CCR7 are crucial for G-protein activation. Membranes of 300-19 cells stably transfected with expression constructs for CCR7 or one of the four receptor mutants were prepared and binding of [35S]GTP{gamma}S was assessed in response to stimulation with CCL19 (5 µg/ml). Results are expressed as fold over basal [35S]GTP{gamma}S binding in the absence of chemokine. Values represent the mean ± s.e.m. of three experiments.





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