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Figure 3


Fig. 3. Effect of DNA-structure-altering agents on XPC-GFP mobility. (A) Monitoring of the uptake of Hoechst 33342 by cells expressing XPC-GFP at different time points. Left panel, Hoechst 33342 staining of DNA; Middle, GFP-fluorescence; right, merged image. (B) Confocal images of a cell expressing XPC-GFP (upper panel), XPB-GFP (middle panel) or GFP-XPA (lower panel) stained with Hoechst 33342 for 30-60 minutes prior to fixation. Left panel, Hoechst staining of DNA; middle, GFP-fluorescence; right, merged image. (C) Strip-FRAP analysis of untreated (light green line) and Hoechst-33342-treated (dark green line) XPC-GFP-expressing cells. (D) Strip-FRAP analysis of untreated (light line) and Hoechst-33342-treated (dark line) cells expressing XPB-GFP (red lines) and GFP-XPA (blue lines). (E) Strip-FRAP analysis of untreated (light line) and actinomycin-D-treated (dark line) cells expressing XPB-GFP (red lines) and GFP-XPC (green lines). (F) Strip-FRAP analysis of untreated (green line), UV-A (light blue line) and UV-C-treated (dark blue line) XPC-GFP-expressing cells.





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