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Figure 3


Fig. 3. Calcineurin autoinhibitory peptide (CaN-AIP) converts synaptic fluctuation into a depression pattern. The standard solution was filled in the tip of pipettes, and additional 40 µM CaN-AIP was back-filled. (A) R1 and R2–R1 values plotted against time. R1 increases (green symbols). The values of R2–R1 fluctuate across zero (dashed line), and remain below this line 30 minutes after CaN-AIP infusion (pink symbols). uEPSCs were sampled every 10 seconds. (B) Paired uEPSCs were sampled in the initial 4 minutes (control) and 30 minutes after the postsynaptic infusion of CaN-AIP. Correlation between R2–R1 and R1 in this unitary synapse plotted before (blue) and after (red) CaN-AIP infusion. CaN-AIP shifts synaptic fluctuation (blue) toward depression (red). (C) Paired uEPSCs in this unitary synapse are evoked by presynaptic spikes (bottom trace) before (blue) and after (red) CaN-AIP infusion. Calibration bars are 20 mseconds/60 pA for uEPSCs and 50 mV for spikes. (D) Other examples (n=9) showing that CaN-AIP converts synaptic fluctuation (thin lines) into depression (thick lines with same color), in which lines denote the correlation between R2–R1 and R1.





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