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Figure 8


Fig. 8. Influence of the integrated synaptic inputs on spike programming through the refractory periods of sequential spikes. The standard deviation of spike timing (SDST; A) and inter-spike intervals (B) under three conditions: (1) 200 synapses with the fluctuating patterns and 0.6-1.6 msecond inter-input interval (open symbols); (2) 300 synapses with uniform pattern/R1 increase and 0.6-1.6 msecond inter-input interval (gray); and (3) 300 synapses with uniform pattern/R1 increase and 0.5-1.0 msecond inter-input interval (black). SDST vs the number of spikes under the three conditions are statistically different (P1-2<0.001 and P2-3<0.001); and ISI vs the number of spikes under three conditions are significantly different (P1-2<0.001 and P2-3<0.001). Values are means ± s.e.m. (C) The measurement of the influence of input strength on the refractory periods of sequential spikes. Blue traces show weak input strength, and red traces show strong input strength. (D) Linear correlation between the normalized stimulus strength and refractory periods for spike 1 (linear slope, –3.1) and spike 3 (slope, –10.4).





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