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Figure 2


Fig. 2. The elevation of intracellular Ca2+ enhances glutamatergic and GABAergic synaptic transmission. (A) Elevation of cytoplasmic [Ca2+] by infusing adenophostin-A into the neurons increases the amplitude of glutamatergic EPSCs (bullet) by ~145% compared with that in the control ({circ}). Inset shows enhanced EPSC waveforms. (B) The intracellular infusions of adenophostin-A raise the amplitude of GABAergic IPSCs (bullet) by ~85% compared with controls ({circ}). Inset shows IPSC waveforms. Glutamatergic EPSCs were isolated by using 10 µM bicuculline, whereas GABAergic IPSCs were isolated by adding 10 µM CNQX and 40 µM DAP-5.





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