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Figure 4


Fig. 4. The elevation of intracellular Ca2+ raises the Vts and prolongs the RP of sequential spikes in regular-spiking neurons. (A) The superimposed waves of measuring absolute RP for spike 3 under control (blue traces) and adenophostin-A (red traces) infusion, where the absolute RP is defined as the duration from a complete spike to a subsequent spike evoked with 50% probability. (B) The relationship between the normalized stimuli and the absolute RP of spike 1 (S1, triangles) or spike 3 (S3, diamonds) under control (open symbols) and adenophostin-A (filled symbols) infusion, in which linear correlations are shifted upward. Values of the absolute RP-3 relevant to the similar stimulus intensity are statistically different (P<0.01). (C) The difference between Vts and Vr (VtsVr) for spike 1 to spike 5 under control ({triangleup}) and adenophostin-A ({blacktriangleup}) infusion, where Vts values relevant to the same number in sequential spikes are statistically different (P<0.01).





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