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Fig. 9. Intracellular Ca²⁺ signaling pathways are essential to the inverse plasticity of axonal and somatic excitability induced by axonal HFA. BAPTA, CaMK(284-302) and CaN autoinhibitory peptide (CaN-AIP) were infused into the neurons via the recording pipette. (A) BAPTA prevents axonal HFA-induced plasticity of excitability dissociated at axons ( $bullet$ ) and soma ( ${circ}$ , n=8). (B) CaMK(284-302) blocks the inverse plasticity of axonal ( $bullet$ ) and somatic excitability ( ${circ}$ , n=11). (C) CaN-AIP lowers threshold stimuli at the axon (TSAx, $bullet$ ) and raises threshold stimuli at cell body (TSCB, ${circ}$ ; n=7). (D) CaN-AIP increases TSAx ( $bullet$ ) and decreases TSCB ( ${circ}$ ; n=8). All results are means ± s.e.m.

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