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Figure 1


Fig. 1. Possible origins of satellite cells. Self-renewing somitic stem cells can be identified by the expression of Pax3 and Pax7, but lack expression of myogenic regulatory factors (MRFs), such as Myf5 and MyoD. These stem cells generate embryonic and foetal myoblasts, which proliferate before differentiating and fusing to produce myotubes. Somitic stem cells may become satellite cells directly if they are partitioned beneath the basal lamina as it forms. The satellite-cell niche might also be transiently occupied by foetal myoblasts, which differentiate to contribute myonuclei for the initial phases of post-natal growth. Such foetal myoblasts might also be specified by the niche to become satellite cells. Satellite cells can self-renew, and produce satellite-cell-derived myoblasts that proliferate and differentiate to contribute myonuclei to growing muscle.





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