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Figure 8


Fig. 8. Illustration of a hypothetical mechanism for the role of HIF1 in the control of keratinocyte migration during wound closure. The disruption of the integrity and cohesion of the keratinocyte monolayer consequent to scratch wounding activates PI3K signalling, which leads to an increased expression of HIF1{alpha} and results in the upregulation of the HIF1 target genes among which is LAMA3 that encodes the {alpha}3 subunit of laminin-332 and reflects the upregulated synthesis of laminin-332. Enhanced deposition of laminin-322 to the ECM, strongly influences the keratinocyte adhesion and their migration capacity.





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