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Figure 2


Fig. 2. Memory for objects is impaired during aging in both SynI–/– and SynII–/– mice. The object-recognition performance of WT, SynI–/– and SynII–/– mice was analyzed in young (A), adult (B) and aged (C) mice (eight to ten mice per group). The two test sessions were carried out 3 and 24 hours after the presentation of the first pairs of objects and the percentage of time spent on the new object was plotted as means ± s.e.m. Statistical analysis was performed by using one-way ANOVA. Young: F(2,27)Time 0hrs = 0.91, not significant; F(2,27)Time 3hrs = 0.41, not significant; F(2,27)Time 24hrs = 0.94, not significant. Adult: F(2,35)Time 0hrs = 1.15, not significant; F(2,35)Time 3hrs = 1.88, not significant; F(2,35)Time 24hrs = 5.38, P<0.01. Aged: F(2,30)Time 0hrs = 2.79, not significant; F(2,30)Time 3hrs = 0.94, not significant; F(2,30)Time 24hrs =16.93, P<0.001. This was followed by the Bonferroni's multiple comparison test (*P<0.05, **P<0.01 and ***P<0.001 for either SynI–/– or SynII–/– vs WT).





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