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Figure 8


Fig. 8. Model describing the effects of depletion of TbCentrin2 or TbCentrin4. In normal cells (middle), duplication and segregation of basal bodies (green), flagella (gray) and kinetoplasts (small blue squares) are followed by division of the nuclei (large blue circles). Cytokinesis initiates at the anterior end of the cell only after full segregation of the nuclei, with the more-posterior daughter nucleus positioned between the segregated kinetoplasts. The cytokinetic furrow forms in between the segregated organelles and partitions them equally into daughter cells. The FAZ (red) is believed to have an important role in the formation of the cytokinetic furrow. In cells depleted of TbCentrin2 (left), duplication/segregation of basal bodies and kinetoplasts is inhibited, whereas the flagellum and nucleus duplicate normally. Formation of the new FAZ is also inhibited, possibly explaining the subsequent inhibition of cell division. In TbCentrin4-depleted cells (right), duplication and segregation of basal bodies, kinetoplasts, flagella and FAZ appear normal. Nuclear division, however, appears delayed relative to cell division, leading to formation of 1K2N and zoid daughters.





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