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Figure 1


Fig. 1. Notch signaling pathway, and domain organization of Notch receptors and DSL ligands. (A) Model for the major events in the Notch signaling pathway. Signals initiated by the engagement of ligand (1) lead to metalloprotease (MP) cleavage at site S2 (2). This proteolytic step allows the cleavage of Notch by the {gamma}-secretase complex at site S3 within the transmembrane domain (3) and release of intracellular notch (ICN) from the membrane. ICN translocates to the nucleus (4), where it enters into a transcriptional activation complex with CSL and MAM, inducing the transcription of target genes (5). (B,C) The domain organization of Notch receptors (B) and DSL-family ligands (C) from fly, human and worm. TM, transmembrane domain; NEC, Notch extracellular subunit.





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