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Figure 6


Fig. 6. Model for the assembly of Notch ternary complexes. A high-affinity interaction between the N-terminal RAM peptide of Notch and the BTD of CSL is likely to be the first event in the assembly of Notch transcriptional activation complexes. This step allows the lower-affinity ANK domain to bind at its docking site, resulting in ordering of the ankyrin-like N-cap and first repeat of the ANK domain. The interface between the ANK domain and the RHR-N (N) and RHR-C (C) domains of CSL create a composite surface for the binding of MAM, which recruits p300 or CBP. Higher-order homotypic assemblies of Notch complexes or heterotypic assemblies with other transcription factors might be required for the transcription of specific Notch targets.





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