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Figure 3


Fig. 3. ILK also localizes to the centrosome. Data from a SILAC-based unbiased proteomic screen place ILK in the centrosome, and indicate that it interacts with tubulin and tubulin-binding proteins to aid in the organization of the mitotic spindle. Binding partners of ILK include -tubulin, -tubulin, RUVBL1 and RUVBL2. The inhibition of ILK activity or expression inhibits Aurora-A–TACC3–ch-TOG interactions, which indicates that ILK might be important in mitotic-spindle assembly.





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