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Figure 2


Fig. 2. The dynamics of STIM1 oligomerization and subplasmalemmal clustering upon moderate and strong ER Ca2+ depletion was limited, while subplasmalemmal STIM1 clustered repetitively at focal points. (A-D) Representative tracings of the effect of 100 µM histamine on [Ca2+]ER (A), STIM1 oligomerization (B), subplasmalemmal STIM1 clustering (C) and [Ca2+]cyto (D) in Ca2+-containing buffer followed by removal of Ca2+ in the presence of histamine. (E) Respective statistical evaluation of the experiments displayed in A (n=12), B (n=8), C (n=6) and D (n=6). (F) Spatial reversibility of subplasmalemmal STIM1 clusters and the histamine-induced degradation of pre-existing STIM1 clusters: i, pre-existing STIM1 clusters under resting conditions; ii, histamine induced disassembly of STIM1 cluster; iii, reassembly of STIM1 clusters upon removal of extracellular Ca2+.





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