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Figure 5


Fig. 5. The developmental consequences of Dph4 mutation. (A-D) Dph4 homozygous mutants are small in size. (A) E10.5 embryos: left, wild-type embryo; centre and right, two homozygous mutant embryos. (B) E11.5 embryos: left, wild type; right, homozygous mutant. (C) E12.5 and E13.5 embryos: left, E12.5 wild-type embryo; centre, E13.5 wild-type embryo; right E13.5 homozygous mutant embryo, to illustrate the ~1-day developmental delay. (D) E13.5 embryos: left, wild type; centre and right, two homozygous mutant embryos. (E-G) Dph4 homozygous mutants have a preaxial polydactyly. (E) Hindfoot of an E14.5 homozygous embryo. (F) Hindfoot of an E16.5 homozygous embryo. (G) Stain.





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