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Figure 4


Fig. 4. MSH6 is recruited to the site of laser irradiation via its N-terminal region. (A) Schematic representation of the MSH6 and deletion mutants (left) and the results of recruitment experiments (right). Black and gray boxes indicate PCNA-binding motif and MSH2-binding domains, respectively. (B) Recruitment of MSH6 deletion mutants. Arrows indicate the sites of irradiation. (C) Accumulation kinetics of GFP-tagged MSH6 and its deletions. Data are means ± s.e.m. of 3-5 independent experiments. (D) Accumulation of mDR-MSH2 in HCT116 by coexpression of GFP-MSH6 (78-1360).





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