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Figure 5


Fig. 5. MLH1 is recruited to the site of laser irradiation via its MutS-binding domain. (A) Colocalization of endogenous MLH1 with {gamma}H2AX after laser irradiation in HeLa cells (upper panels). There was no accumulation of MLH1 at laser-irradiated site in HCT116 cells (lower panels). (B) Recruitment of GFP-MLH1 to the site of laser irradiation in HeLa cells. (C) Schematic representation of the recruitment of MLH1 deletion mutants. Black and gray boxes indicate PCNA-binding motif and MSH2-binding domain, respectively. The MLH1 deletion mutant containing residues 1-389 is recruited to irradiation sites, whereas that containing residues 389-756, is not.





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