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Figure 6


Fig. 6. MSH2 and MSH3 are recruited to UV-induced DNA damage in an NER-dependent manner. (A) Immunostaining of MSH2 and PCNA in locally UV-irradiated (100 J/m2) NER proficient (XPA-WT, labelled WT) and deficient cells (XPA-C2, labelled XPA). (B) Immunostaining of MSH3 and PCNA in locally UV-irradiated (100 J/m2) NER proficient (upper panels) and deficient cells (lower panels). (C) MSH3 is recruited to UV-induced DNA damage via its PCNA-binding motif in XPA-WT cells. GFP-MSH3 (1-57) harboring PCNA-binding domain accumulates at UV-irradiated sites (upper panels), whereas mutation in the PCNA-binding motif and MSH3 without the PCNA-binding domain abrogates the accumulation (middle and bottom panels, respectively).





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