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Figure 10


Fig. 10. GA-induced ErbB2 degradation is sensitive to chloroquine. SK-BR-3 cells were incubated with GA with or without chloroquine (CQ) for the times indicated and lysed. Proteins were separated by SDS-PAGE and transferred to membranes for western blotting and detection of ErbB2. (A) Western blots. Top, GA alone; bottom, GA and CQ. Arrow: ca. 135-kDa ErbB2 fragment. (B) Bands were quantified by scanning densitometry and plotted as the percentage of the signal at time=0 remaining at each time point.





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