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Figure 4


Fig. 4. Intracellular domains of the ErbB receptors have dimerization activity, as shown by the mammalian two-hybrid assay. GAL4 and VP16 fusion proteins were encoded by the pBIND and pACT constructs, respectively, as described in Materials and Methods. NIH3T3 cells were co-transfected with a pair of expression plasmids encoding the receptor cytoplasmic domains indicated, and their luciferase activities were measured as described in Materials and Methods. Bars show the fold changes in luciferase activity relative to the value induced by the empty vectors.





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