spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. The RRR motif in the first intracellular loop of Nav1.8 serves as an ER-retention/retrieval signal. (A) COS-7 cells transfected with Nav1.8-Myc were immunofluorescently labeled with antibodies against Myc and the ER marker calnexin, or the Golgi marker GM130. (B) Schematic of the intracellular segments of Nav1.8 and the amino acid sequence of the first part of the first intracellular loop (1L). (C) Plasmids expressing Myc-CD8{alpha}, Myc-CD8{alpha}-KKTN, or a series of constructs with the C-terminus of CD8{alpha} linked to the second intracellular loop (2L) or the various segments of 1L of Nav1.8 were transfected into COS-7 cells. Transfected cells were immunofluorescently labeled with antibody against Myc or calnexin. The images are representative of at least three independent experiments. Scale bars: 10 µm.





Right arrow Return to article