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First published online September 17, 2008

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Dynein takes the driver's seat

Several studies have suggested a role for the microtubule (MT) motor cytoplasmic dynein in both centrosome reorientation and nuclear positioning during directed cell migration. On page 3187, Jennifer R. Levy and Erika L. F. Holzbaur investigate how dynein contributes to these processes in migrating fibroblasts. The authors show that knockdown of dynein in these cells inhibits centrosome reorientation and causes defects in nuclear movements – nuclear migration slows and nuclei are mislocalised to the rear of motile cells. In addition, monolayer wounding of control cells reveals that dynein induces dramatic nuclear rotation at the wound edge. Surprisingly, the rotation of the nucleus is not accompanied by rotation of the centrosome but, instead, remains independent of centrosome positioning, with the centrosome remaining stably positioned between the nucleus and the leading edge. The authors propose that dynein contributes to directed cell migration by maintaining the centrality of both the centrosome (by tethering microtubule plus ends at the cortex) and nucleus (by asserting force directly on the nucleus). Dynein, therefore, seems to be a central component in establishing polarity and in translocation of the cell body in migrating fibroblasts.

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Related articles in JCS:

Dynein drives nuclear rotation during forward progression of motile fibroblasts

Jennifer R. Levy and Erika L. F. Holzbaur
JCS 2008 121: 3187-3195. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?