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Figure 4


Fig. 4. Genetic ablation of TPL2 blocks pre-TNF{alpha} expression at the cell surface. BMDMs were stimulated with LPS (1 µg/ml) for (A,B) 1.5 or (C,D) 3 hours in (A,C) the presence or (B,D) absence of Brefeldin A. Permeabilised (A,C) and intact (B,D) cells were stained with PE-conjugated anti-TNF{alpha} and APC-conjugated anti-F4/80. Histograms are gated on F4/80+ cells. Grey histograms denote wild-type cells and solid lines denote TPL2-deficient cells. Unstimulated cells (solid lines) and isotype-control staining (grey histogram) are shown in the bottom panel.





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