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Figure 8


Fig. 8. Signalling pathway underlying the ET-induced enhancement of nuclear CaTs. (A) Original recordings of cytoplasmic (black) and nuclear CaTs (red) before and after application of 0.25 µM BQ-123 (left) or 3 µM 2-APB (right) and following additional application of 10 nM ET. (B) Means ± s.e.m. of peak cytoplasmic and nuclear [Ca2+] following exposure to ET for 10 minutes in the absence and presence of BQ-123 (n=10), U-73122 (n=7), 2-APB (n=12) and xestospongin C (n=7).





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