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Figure 1


Fig. 1. The role of PI3K in mediating long-term migration to fMLP. Neutrophils were either uninhibited (UT, C57Bl/6), pan-PI3K-inhibited (LY294002), PI3K{delta} inhibited (IC87114), wild type (C57Bl/6) or PI3K{gamma}–/–. (a,e) Number of migrating human (a) or murine (e) neutrophils to fMLP. (b,f) Directionality of human (b) or murine (f) neutrophil migration to fMLP. (c,g) Speed of human (c) or murine (g) neutrophil migration to fMLP. (d) Migratory distance of (d) human neutrophil over 2 hours or (h) murine neutrophils over 4 hours to fMLP. n>4; *P<0.05, ANOVA with Bonferroni correction.





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