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Figure 9


Fig. 9. Schematic representation of mammalian WNT3a-sensitive signaling pathways. The scheme represents a work-in-progress of our understanding of WNT3a-stimulated pathways in mammalian cells. JNK activation, crosstalk between the WNT3a–β-catenin canonical and WNT3a-JNK pathways in mouse F9 embryonal stem cells are highlighted. Constitutively active mutants of signaling molecules whose expression provokes activation of JNK in the absence of WNT3a are shown in green. Dominant-negative versions of signaling molecules, siRNAs and inhibitors that can effectively attenuate or block WNT3a-induced JNK activation or WNT3a-stimulated LEF/TCF-sensitive transcription are shown in red. The vectoral flow of information from WNT3a to JNK activation and from WNT3a to LEF/TCF transcription is displayed with arrows.





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