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First published online January 10, 2008

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Cyclin' without integrin

To progress through the G1 phase of the cell cycle, most cells must switch on production of cyclin D1. In fibroblasts, cyclin D1 is not expressed unless cells form integrin-based adhesions to the substrate, but it is not known whether this is a general requirement. Now Richard Assoian and colleagues (p. 226) report that, in mammary epithelial cells, cell-substrate adhesion is not required for cyclin D1 expression. The authors show that cyclin D1 is expressed when cells are grown on agarose (to eliminate integrin-based adhesions) or when E-cadherin is knocked down (to block the formation of adherens junctions). Expression is only blocked when both forms of adhesion are abolished, which indicates that cell-cell adhesion at adherens junctions compensates for a lack of cell-substrate adhesion. The authors show that either form of adhesion activates the GTPase Rac, and that Rac signalling is necessary for cells to progress beyond G1 phase. These results highlight the diverse extracellular cues that promote growth in different cell types.

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Related articles in JCS:

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion

Alaina K. Fournier, Latoya E. Campbell, Paola Castagnino, Wendy F. Liu, Betty M. Chung, Valerie M. Weaver, Christopher S. Chen, and Richard K. Assoian
JCS 2008 121: 226-233. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?