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Fig. 3. Ca²⁺_[i] oscillations are coordinated between contacting myofibroblasts but random between fibroblasts and non-contacting cells. The periods between every two consecutive Ca²⁺_[i] peaks in the Fura-2 Em₃₄₀/Em₃₈₀ fluorescence ratios of myofibroblasts (A) and fibroblasts (B) were compared over time for every possible cell pair combination within one image field (myofibroblasts, n_exp=25 and n_cells=193; fibroblasts, n_exp=18 and n_cells=184). All matching period pairs (square data points) obtained from cells that are not in physical contact are plotted as longer period versus shorter period above the diagonal (non-contacting pairs in myofibroblasts, n=324 and in fibroblasts, n=482). Period pairs obtained from all physically contacting cells are plotted as shorter period versus longer period below the diagonal (contacting pairs in myofibroblasts, n=60 and in fibroblasts, n=55). The occurrence of identical period pairs is colour-coded and normalised to the total number of data points in each condition (scale in %). The deviation of a period pair (one example encircled), i.e. its orthogonal distance to the diagonal, is demonstrated with a yellow line in A. By dividing the deviation by the distance z of the intersection point between the orthogonal and the diagonal to the origin (red section of diagonal) the relative deviation can be obtained (see Materials and Methods). The mean relative deviation is the average of all relative deviations and is represented as a dotted line.

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