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Figure 7


Fig. 7. SHP-2 lies downstream of Abl kinases during PDGF-mediated mitogenesis. Abl/Arg double null fibroblasts, infected with vectors (Migr1, MigCD4, PK1), Abl and Arg (MigCD4-Abl, PK1-Arg), and/or wild-type or mutant forms of SHP-2 (Migr1-SHP2-C459S, Migr1-SHP-2-E76K), were serum-starved, stimulated with PDGF-BB (12.5 ng/ml) for 16-20 hours, pulsed with tritiated thymidine, and harvested. (A) Results from one representative experiment; values are mean ± s.d. (some error bars are too small to be visible). Lysates from infected cells were probed with the indicated antibodies. (B) Composite of three independent experiments; values are mean ± s.e.m. Tritiated thymidine incorporation is expressed as a percentage of vector-transfected cells. *P≤0.05, **P≤0.01, ***P≤0.001, using a one-way ANOVA followed by a Bonferroni post-hoc test.





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