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Figure 1


Fig. 1. Wdb modulates the IIS-regulated effects of FOXO in the differentiating eye. Overexpression of foxo in the differentiating eye from the foxoGS9928 insertion using the GMR-GAL4 driver produces a characteristic reduction in the adult eye (D) (Goberdhan et al., 2005) compared with the wild type (A). This effect is completely suppressed by co-overexpressing a UAS-Akt1 construct (G). Overexpressing wdb from the wdbGS9548 insertion produces a disorganised and slightly reduced eye (B). Co-overexpression of FOXO and wdbGS9548 drastically enhances the FOXO phenotype (E), an effect that is completely suppressed by Akt1 (H; compare with I, where Akt1 and Wdb are expressed in the absence of FOXO). An EP insertion in wdb, wdbEP3559, has very little effect on its own (C), but enhances the FOXO phenotype (F).





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