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Figure 10


Fig. 10. Model for Tf and EGF internalization and sorting relative to EEA1. The majority of liganded EGFR and TfR internalize through distinct plasma membrane regions, entering into vesicles that contain Rab5. The active EGFR recruits more Rab5 resulting in a higher density of this GTPase in EGF-containing vesicles compared to Tf-containing vesicles. Both types of vesicles interact with EEA1-enriched endosomes, but only EGF-containing vesicles can interact strongly, and fuse. Tf-TfR-containing vesicles move to the perinuclear recycling endosome, while the EGF-EGFR complex is now sequestered by EEA1-enriched endosomes. In this model, EEA1 marks the entry point into the degradative pathway.





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